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Inflammatory Bowel Disease - Crohns Vs Ulcerative Colitis

Both :

• Chronic inflammatory bowel disease
• Unknown etiology
• Genetic predispositions
• Diarrhoea
• Bleeding (may be anaemic)
• Perforation
• Can get carcinoma colon
• "Toxic"  dilatation of colon
• Episcleritis , iritis, uveitis
• Clubbing
• Large joint arthropathy, sacroilitis
• Ankylosing Spondylosis
• Amyloidosis
• Renal stones
• Treated with fluids
• Treated with immunomodulators (steroids, azathioprine)
• Treated with 5 ASA analogues (e.g.. sulfasalazine)

Crohns  can occur anywhere from mouth to anus (mostly terminal ileum) , whereas Ulcerative colitis  occurs in rectum / colon.

Crohns , unlike ulcerative colitis,  has "skip lesions" (i.e. there can be normal areas in-between the lesions)

Crohns is more likely to have strictures and fistulae.

Reference: Mostly from : Murray Longmore, Ian Wilkinson, Estee Torok . Oxford Handbook of Clinical Medicine, 5thEdition. Oxford, Oxford University Press, 2001, p232 - 235.

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